CP2 Biotech

La missione di CP2 Biotech è portare alla sperimentazione clinica delle molecole bioattive derivanti dalla ricerca di base

Il motto di CP2 è «from bench to bedside.»

Prodotti e servizi

«dal laboratorio alla clinica» ossia «From bench to bedside»

La missione di CP2 è di portare fino alla fase di sperimentazione clinica composti bioattivi sviluppati nei laboratori di ricerca del Dipartimento di Biotecnologie e Bioscienze dell’Università di Milano-Bicocca.

Tutti i composti prototipo (hits) e pilota (leads) per lo sviluppo di farmaci sono brevettati e proprietà dell’Università Bicocca. L’attività di CP2 è perciò focalizzata alla valorizzazione di molecole sintetiche, naturali e semisintetiche derivate da trasformazione chimica di sostanze naturali, attraverso la realizzazione dei seguenti passaggi della fase preclinica:

  • Computer-assisted drug design
  • Sintesi di hit compounds
  • Esperimenti in vitro di interazione con il target, attraverso tecniche SPR, NMR, calorimetriche
  • Da Hit a lead: farmacocinetica, metabolismo, stabilità, tossicità in vitro ed in vivo.

I principali assets della spinoffs riguardano attualmente candidati farmaci nei seguenti settori:

  •  adiuvanti vaccinali (in collaborazione con Croda)
  • farmaci per Immunoterapia tumorale
  • Farmaci diretti al dolore neuropatico ed alle neuroinfiammazioni
  • Farmaci contro Inflammatory Bowel Disease (IBD)
  • Farmaci per infiammazioni vascolari ed aterosclerosi

Team

Prof. Barbara Costa (cofondatrice), Prof. Francesco Peri (fondatore), Dott. Matteo Piazza (amministratore unico)

Contatti

Francesco Peri: francesco.peri@unimib.it;

Barbara Costa: barbara.costa@unimib.it;

Matteo Piazza: mpiazza@menarini-biotech.it

Nanoencapsulation made easy through reactive nanoemulsion solvent evaporation

DESCRIPTION

NanOcApps aims at developing a robust and high throughput method for the preparation of crosslinked nanocapsules in the kg range, at low cost and having flexible payload. The application spectrum for such formulations is vast and includes controlled release, selective delivery, catalysis and cosmetics. Capsules production is based on an original modification of the mini emulsion solvent evaporation method, while crosslinking is realized through a facile and fully scalable approach: the prefunctionalization of cellulose (a cheap, renewable raw material) with a curing agent. Such an approach allows to encapsulate every water insoluble material, including liquids. An additional advantage of the process deals with the possibility to recover the nanocapsulses as reversible aggregates by coagulation. Such a process makes it possible to proceed by standard filtration instead of centrifuging. The process is batch and designed to provide samples in the kg range, continuous production is under development.

PRODUCTS AND SERVICES

Nanoencapsulation of active compounds

TEAM

Luca Beverina, Sara Mattiello, Mauro Sassi

CONTACTS

info@u4i.it

STATUS

Concluded. Seeking funding.

 

UPDATE

The project currently pursues two possible exploitation paths:

  • Selling of the technology
  • Joint development with partners
PROJECT DURATION

24 months

GRANTS

63.000 €

 

YEAR OF ACTIVITY (IPF)

2018

ScAling-up of a systeM ANTi-particulate matter, anti-coronavirus, biocide self-heAling (SAMANTA)

DESCRIPTION

The project is a scaling-up innovation of a filtering system (patent pending; P06972 IT) suitable for any indoor air filtration application for the retention of all particulate matter (inorganic, organic and biological) with a size (diameter) greater than 4 nm with a filtration efficiency >99.99%; the system allows the inactivation of COVID-19 and the self-healing and a final biocide action against all other biological elements. The system is based on a heat treatment for the inactivation of COVID-19 and for the combustion of all the particulate matter collected on a filter resulting in a completely biocide and self-healing eliminating the production of special waste. The system is designed to be independent from all possible variants of COVID-19 and any future pandemic biota, being the system based on a universal (thermal) method of inactivation (possible choice of any temperature) and destruction of any biological structure based on carbon chemistry

PRODUCTS AND SERVICES

Filtering system

TEAM

Luca Ferrero, Ezio Bolzacchini, Giulio Ceppi, Chiara Rostagno, Marco Zoppo Vigna

CONTACTS

info@u4i.it

STATUS

Ongoing

UPDATE

The SAMANTA system is at the initial stage of market analysis

PROJECT DURATION

18 months

GRANTS

70.000 €

YEAR OF ACTIVITY (IPF)

2021

UBCARE SRL

Presentation

UB-Care srl is an innovative spin-off that aims to apply scientific research to the market of nutraceuticals, cosmetics, medical devices and food supplements with a strong background in different areas of scientific research and regulations in the markets of interest.

Products and Services

UB-Care consulting service is directed to customers with the need to evaluate solutions to specific biosafety control issues for which specific tests are not yet available. It has its own laboratories operating in these areas:

  • Microbiology Division: analysis of safety and efficacy of finished products, in accordance with current legislative regulations and through internal protocols
  • Cellular Biology and Toxicology Division: evaluation of synthesis of extracellular matrix proteins, molecular mechanisms related to skin aging, pathways related to oxidative stress and tissue regeneration.
  • Molecular Biology Division: evaluation of molecular pathways involved in the efficacy and biocompatibility of raw materials and finished products (Test in vitro).
  • Biochemistry laboratory: chemical, physical and biochemical tests performed to evaluate the structural and efficiency properties of molecules and enzymes.
  • Clinical Division: safety and efficacy assessments of finished products performed on healthy volunteers in compliance with international guidelines and ethical principles established by the Helsinki Declaration. The experimental protocol is created specifically for the customer.

Team

Cristina Maccario
Sabrina Sommatis
Roberto Mocchi

Contacts

Cristina Maccario
Phone: +39 03821752395
E-mail: info@ub-careitaly.it

Website: https://www.ub-careitaly.it

PHARMAEXCEED SRL

PharmaExceed srl is a biotechnology company that develops exosome products based on Secretome from mesenchymal cells for research and therapeutic purposes. PharmaExceed’s mission is to transfer such innovative products to medical research by exploiting the potential of a-cellular solutions based on secretome from mesenchymal cells, even in combination with biomaterials (such as fibroin silk and alginate). Lyosecretome is a product that will allow researchers to experiment with exosome-based biotherapeutics in a standardized, affordable and much simpler way.

PRODUCTS AND SERVICES

Development, production and marketing of innovative products or services with high technological value, and more specifically:

  • the research and technological development of innovative products with a high technological content in the pharmaceutical, cosmetic and biomedical field,
  • the production and marketing of drugs, medical devices and cosmetic products with a high technological content.

TEAM

Maria Luisa Torre PhD – Chief of Scientific Board; Marzio Sorlini MSc. Eng., PhD – Chief Operating Officer and Director; Sara Perteghella PhD – Scientific Advisor; Paolo Gaetani MD – Scientific Advisor; Angelo Guido Corsico MD, PhD – Scientific Advisor; Alessandra Ubezio MSc. Eng. Advisor

CONTACTS

Sara Perteghella

Phone: +39

E-mail: info@pharmaexceed.com

Website: https://www.pharmaexceed.com

P4P SRL

PRESENTATION

P4P srl develops innovative materials in order to create drug delivery systems for achieving a controlled active molecules release over time for applications in life-science sector.

PRODUCTS AND SERVICES

P4P proposes SmartH, a highly porous, biocompatible and biodegradable polymer, able to release in a totally controlled way active molecules to be used as drug delivery in the pharmaceutical field and as support for traditional packaging in order to monitor product the quality and safety.

SmartH composition, application and manufacturing process is protected with a patent pending formula from September 2019.

TEAM

Laura Catenacci, Chief Knowledge Officer; Marco Corti, CEO; Franca Scocozza, COO; Giuseppe Tripodo, CTO; Advisors: Ferdinando Auricchio, Gloria Brusotti, Enrica Calleri, Michele Conti, Gabriella Massolini.

CONTACTS

Franca Scocozza

Phone: +39 3338197568

E-mail: info@p4psrl.com

Website: https://www.p4psrl.com/

ETICHUB SRL

PRESENTATION

EticHub srl designs and develops new cosmetics, offering services in the fields of know how, testing and product architecture.

PRODUCTS AND SERVICES

It offers testing, consulting and product development services to companies and individuals in the cosmetic field. The academic background allows it to study the product by enhancing its strengths by making patents, protocols and advanced research accessible to the industry.

TEAM

Mariella Bleve, Paola Perugini

CONTACTS

Paola Perugini

Phone: +39 0382 987193

E-mail: Info@Etichub.It

Website: https://www.etichub.it

EUFAN SRL

PRESENTATION

euFan srl develops customized solutions for food & drug safety, quality and technology.

PRODUCTS AND SERVICES

  • Food : production of applied research and consulting services in the field of design and support of prototypes creation of food preparations, quality and safety control, shelf life studies and analytical characterizations aimed at marketing and / or nutrition.
  • Drug: development and validation of analytical methods for the identification and quantification of active compounds, impurities and by-products in the pharmaceutical, nutraceutical, phytochemical and biomedical fields. Development of bio-chromatographic systems for the study of interactions between drugs and bio-macromolecules of pharmaceutical interest. Scale-up realization of analytical methods.

TEAM

Monica Bononi, Gloria Brusotti, Enrica Calleri, Gabriele Caccialanza, Fernando Gabriele Giorgio Tateo, Adele Papetti

CONTACTS

Gloria Brusotti

Phone:

E-mail: gloria.brusotti@eufan.it

Website: http://www.eufan.it/

ENGENOME SRL

PRESENTATION

enGenome srl is an innovative start-up, born from the Laboratory of Bioinformatics, Mathematical Modelling and Synthetic Biology (BMS) and from the BioMedical Informatics Laboratory “Mario Stefanelli” (BMI). It provides bioinformatics partnership, offering services and solutions to ensure the success of translational research projects, thanks to the technological and methodological expertise for the management and analysis of sequencing data.

PRODUCTS AND SERVICES

It provides the experience and software technology for the analysis and interpretation of sequencing data in clinical and research settings. Creation of bioinformatics solutions for the interpretation of molecular data generated by Next Generation Sequencing technologies.

For laboratories that use DNA-sequencing in oncology, enGenome offer genetic reports generated by a proprietary bioinformatics algorithm that, leveraging on artificial intelligence, is able to detect cancer mutations where other state of the art technologies fail.

For Mendelian diseases, enGenome offers genetic reports that comply with the American College of Medical Genetics and Genomics for the interpretation of sequence variants identified via NGS.

TEAM

Ettore Rizzo, CEO; Ivan Limongelli, CTO; Susanna Zucca, Chief Bioinformatics Officer; Massimiliano Leone, Web Developer; Giuseppe Marrari, Back-end developer; Federica De Paoli, Bioinformatician; Martina Forte, Marketing Specialist; Luisa Cucugliato, Sales Representative; Cristina Bonzi, Back-Office

CONTACTS

Ettore Rizzo

Phone: +39 0382 985361E-mail: info@engenome.com

Website: https://www.engenome.com/

BAC3GEL LDA

PRESENTATION

Bac3Gel LDA startup is based on a revolutionizing technology to produce artificial mucus of different body districts in healthy and pathological conditions, including intestinal, lung, vaginal and stomach. provides Pharma and Biotech with high throughput in vitro preclinical models that optimize the development of antimicrobial agents, probiotics, prebiotics and other food integrators. Bac3Gel technological platform enables the production of 3D universal substrates to culture, transport, preserve and deliver bacteria.

PRODUCTS AND SERVICES

Distribution of in vitro preclinical models and consultancy services for pharma and biotech that develop antimicrobial agents, pre- and probiotics and other dietary supplement.

Preclinical in vitro models are distributed in different formats in syringes or multi-well culture plates, to suit conventional test platforms, such as cell monolayers, Transwell® media, PAMPA plates or microfluidics devices.

TEAM

Daniela Pacheco, Sebastião van Uden, Paola Petrini, Livia Visai, Sonja Visentin

CONTACTS

Sebastião van Uden

Phone Number: +351918236302

E-mail: contact@bac3gel.com

Website: https://bac3gel.com/

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