Method for the simulation of coronary changes and/or for the risk assessment of myocardial ischemia

ABSTRACT

The present invention relates to a method for simulating coronary changes and / or for assessing the risk of myocardial ischemia for congenital coronary anomalies, preferably dynamic exertional ischemia. In particular, the present invention refers to a method capable of describing the variations of the coronary (abnormal and non-abnormal) at rest and / or under stress through a dynamic, patient-specific (non-static) model reaching the assessment of the risk of ischemia of the myocardium, preferably dynamic exertional ischemia, of the individual patient.

DESCRIPTION

The present invention relates to a method for simulating coronary changes and / or for assessing the risk of myocardial ischemia, preferably dynamic exertional ischemia.

This method includes: i) in-vivo acquisition of medical images and / or clinical data of the individual patient necessary to obtain a “specific patient” model and ii) computerized (in-silico) analysis of the images and / or data obtained from the phase in-vivo. The method according to the present invention is therefore intended as a method implemented by an electronic processor, i.e. a computer-implemented method. The hybrid in-vivo / in-silico combination of the method of the present invention is capable of evaluating the risk of coronary compression and the relative lack and / or reduction of blood supply during exertion.

ADVANTAGES

• Patient-specific, personalized evaluation
• Not invasive
• Method implemented by an electronic computer
• Physical effort safety intervals

APPLICATIONS

• Diagnostic method of coronary changes
• Assessment of the risk of myocardial ischemia, preferably dynamic exertional ischemia
• Assessment of ischemic risk in coronary congenital anomalies

INVENTORS

Michele Conti, Mauro Lo Rito

KEYWORDS

coronary anomalous; computational simulation; mathematical modeling; 3D cardiovascular imaging; computational fluid dynamics; personalized coronary risk

PRIORITY NUMBERS

10202000001203

APPLICANT

Università di Pavia 50% Gruppo San Donato 50%