Sede: Università degli Studi di Pavia

EUFAN SRL

PRESENTATION

euFan srl develops customized solutions for food & drug safety, quality and technology.

PRODUCTS AND SERVICES

  • Food : production of applied research and consulting services in the field of design and support of prototypes creation of food preparations, quality and safety control, shelf life studies and analytical characterizations aimed at marketing and / or nutrition.
  • Drug: development and validation of analytical methods for the identification and quantification of active compounds, impurities and by-products in the pharmaceutical, nutraceutical, phytochemical and biomedical fields. Development of bio-chromatographic systems for the study of interactions between drugs and bio-macromolecules of pharmaceutical interest. Scale-up realization of analytical methods.

TEAM

Monica Bononi, Gloria Brusotti, Enrica Calleri, Gabriele Caccialanza, Fernando Gabriele Giorgio Tateo, Adele Papetti

CONTACTS

Gloria Brusotti

Phone:

E-mail: gloria.brusotti@eufan.it

Website: http://www.eufan.it/

ECATES SRL

PRESENTATION

EcateS srl is a young and new reality in the field of aerial and terrestrial surveys for the geological, naturalistic, agricultural and cultural heritage sectors. The company has UAV for aerial surveying and different solutions for terrestrial surveyng couple with RGB and multispectral sensors, GPS and georadar.

PRODUCTS AND SERVICES

The sectors in which Ecates is active are geology, cultural heritage and agricolture. The main activities are:

  • aerial (UAV technology) and terrestrial photogrammetry;
  • geological surveying of areas, rockwalls, landslides, quarry and production of 2D and 3D maps and models;
  • Identification and characterization of archeological sites, soil study and stratigraphic analysis;
  • Production of 3D models of archeological artifact, fossils and hystorical bilding;
  • Precision farming services, production of maps indexes;
  • GIS and BIMM/CAD analysis.

TEAM

Matteo Crozi, Sergio Martini, Luisa Pellegrini, Ceare Perotti, Francesco Zucca

CONTACTS

Matteo Crozi

Phone: +39 0382 98 58 38

E-mail: info@ecates-italia.com

Website: https://www.ecates-italia.com/

BRIGHTSOLUTIONS SRL

PRESENTATION

BrightSolutions srl develops and manufactures state-of-the-art ns, sub-ns DPSS lasers and high brightness diode laser modules.

PRODUCTS AND SERVICES

The activity is oriented towards the development of state-of-the-art diode-pumped solid- state laser systems aimed at superior, efficiency, compactness and reliability, suitable for industrial, aerospace, medical, military and scientific application.

Furthermore, Bright Solutions acquired great experience in setting up industrial production and testing line and in forming professionally skilled personnel for the manufacture of diode pumped solid-state lasers. Its proprietary designs in the field of DPSSL for industrial applications are an indisputable success being today marketed worldwide in the thousands of pieces.

The main areas of applications of products include the following: industrial OEM, airborne and aerospace, medical, military, and scientific markets, and personalised custom solutions.

TEAM

Antonio Agnesi, Giuliano Piccinno, Giancarlo Reali (founding team)

CONTACTS

Antonio Agnesi

Phone Number: +39 0382 583094

E-mail: info@brightsolutions.it

Website: https://brightsolutions.it/

 

ENGENOME SRL

PRESENTATION

enGenome srl is an innovative start-up, born from the Laboratory of Bioinformatics, Mathematical Modelling and Synthetic Biology (BMS) and from the BioMedical Informatics Laboratory “Mario Stefanelli” (BMI). It provides bioinformatics partnership, offering services and solutions to ensure the success of translational research projects, thanks to the technological and methodological expertise for the management and analysis of sequencing data.

PRODUCTS AND SERVICES

It provides the experience and software technology for the analysis and interpretation of sequencing data in clinical and research settings. Creation of bioinformatics solutions for the interpretation of molecular data generated by Next Generation Sequencing technologies.

For laboratories that use DNA-sequencing in oncology, enGenome offer genetic reports generated by a proprietary bioinformatics algorithm that, leveraging on artificial intelligence, is able to detect cancer mutations where other state of the art technologies fail.

For Mendelian diseases, enGenome offers genetic reports that comply with the American College of Medical Genetics and Genomics for the interpretation of sequence variants identified via NGS.

TEAM

Ettore Rizzo, CEO; Ivan Limongelli, CTO; Susanna Zucca, Chief Bioinformatics Officer; Massimiliano Leone, Web Developer; Giuseppe Marrari, Back-end developer; Federica De Paoli, Bioinformatician; Martina Forte, Marketing Specialist; Luisa Cucugliato, Sales Representative; Cristina Bonzi, Back-Office

CONTACTS

Ettore Rizzo

Phone: +39 0382 985361E-mail: info@engenome.com

Website: https://www.engenome.com/

BESHARP SRL

PRESENTATION

beSharp srl provides cloud computing services, aimed at storing and distributing any type of file over the network, as well as hosting, synchronization and backup services. beSharp growing, innovation-driven team is dynamic and always in search of the latest innovation in IT world.

PRODUCTS AND SERVICES

Specilized in Cloud Advisory, Cloud Development and Cloud Architecture, beSharp is an AWS Advanced Consulting Partner and has been carrying out Digital Transformation projects on AWS in all areas, from Cloud migration to Cloud-native development, from IoT and Big Data to Machine Learning.

It offers consulting and/or software development in the Cloud Computing sector and resale of products or services (hardware and software) related to consulting projects. A special mention goes to the business line dedicated to the development of the “Noovolari” Cloud Management Tool suite, which was launched on the market in March 2018.

TEAM

Simone Merlini, CEO, CTO & Co-founder Alessandro Molina, CFO, CMO & Co-founder Nicola Lamberti, Advisor Alessandro Gaggia, Head of Software Development Claudio Pontili, Senior AWS Solutions Architect Nicola Ferrari, Cloud Infrastructure Line Manager Alessio Gandini, Cloud-native Development Line Manager Francesca Adragna, Marketing Specialist Senior DevOps Engineer: Eric Villa, Nicolò Marchesi DevOps Engineer: Andrea Cavagna, Matteo Moroni, Mario Agati, Paolo Di Ciaula, Manuel Petrungaro, Andrea Franzoso, Alessandro Bertini, Damiano Giorgi, Luca Mormile. Arnaldo Derosa, Visual, UX & UI Designer

CONTACTS

Simone Merlini

Phone Number: +39 3397816800

E-mail: info@besharp.it

Website: https://www.besharp.it/

BAC3GEL LDA

PRESENTATION

Bac3Gel LDA startup is based on a revolutionizing technology to produce artificial mucus of different body districts in healthy and pathological conditions, including intestinal, lung, vaginal and stomach. provides Pharma and Biotech with high throughput in vitro preclinical models that optimize the development of antimicrobial agents, probiotics, prebiotics and other food integrators. Bac3Gel technological platform enables the production of 3D universal substrates to culture, transport, preserve and deliver bacteria.

PRODUCTS AND SERVICES

Distribution of in vitro preclinical models and consultancy services for pharma and biotech that develop antimicrobial agents, pre- and probiotics and other dietary supplement.

Preclinical in vitro models are distributed in different formats in syringes or multi-well culture plates, to suit conventional test platforms, such as cell monolayers, Transwell® media, PAMPA plates or microfluidics devices.

TEAM

Daniela Pacheco, Sebastião van Uden, Paola Petrini, Livia Visai, Sonja Visentin

CONTACTS

Sebastião van Uden

Phone Number: +351918236302

E-mail: contact@bac3gel.com

Website: https://bac3gel.com/

BIOMERIS SRL

PRESENTATION

Biomeris srl provides IT tools to support clinical research for data collection and management, mainly addressing the clinical-assistance structures active in the field of scientific research.

PRODUCTS AND SERVICES

It creates an IT infrastructure for the collection and analysis of data from research institutes, both in the biomedical and pharmaceutical fields (clinical tests, hospital admissions, anamnestic data, genetic data), with the aim of integrating and processing them with the same tool.

BIOMERIS is the only firm in italy specializing in installation support for i2b2 (Informatics for Integrating Biology and the Bedside) software that allows users to select patients of interest based on information coming from several sources and to analyze the obtained data.

Mantra is a clinical data collection software focused on flexibility and ease of use for multi-center and multi-role patient management.

IceTrack is the powerful and flexible biobank management software that is easy to use, implementing the standard functions of Biobank Information System and much more.

TEAM

Nicola Barbarini, COO

Mauro Bucalo, CTO

Matteo Gabetta, R&D Manager Morena Stuppia, Product Specialist Anna Alloni, Senior Developer

IT Consultant: Rita De Molfetta, Daniele Segagni, Cristiana Larizza, Giordano Lanzola, Davide Capozzi.

Paolo Magni, Administrative Consultant

Scientific Consultant: Riccardo Bellazzi, Alberto Malovini, Silvana Quaglini.

CONTACTS

Nicola Barbarini

Phone Number: +39 0382 985055

E-mail: info@biomeris.com

Website: https://www.biomeris.it/

A highly stable, protease-resistant e. coli asparaginase

ABSTRACT

L-Asparaginases are used as first line drugs for paediatric Acute Lymphoblastic Leukaemia (ALL) treatment. Yet they are characterized by high in vivo instability, short half-life and the requirement of several administrations. A new E. coli ASNase variant called N24S which tackles these issues has been patented, thus becoming an alternative treatment to successfully address the current challenges of ALL treatment. Preclinical trials in progress. 

DESCRIPTION

The patented asparaginase N24S variant has improved characteristics in terms of increased in vivo stability, longer half-life, reduced sensitivity to specific proteases that are over-expressed by resistant leukaemia lymphoblasts, and overcomes drug activity and pharmacokinetics of classical asparaginase.

This characteristics render it an alternative treatment to reduce the number of administrations and to successfully address the current challenges of Acute Lymphatic Leukemia treatment.

The fact that the molecule carries only one point mutation compared to the natural one, maintaining the enzymatic activity unaltered and, indeed, presenting further useful aspects, represents a great advantage that drastically reduces both the time and the costs of its introduction into the clinic. Preclinical trials in progress.

ADVANTAGES

  • Preserved asparaginase and glutaminase activities
  • Long-term storage stability
  • Improved thermal parameters
  • Outstanding resistance to proteases derived from leukaemia cells

APPLICATIONS

  • First line drugs for paediatric Acute Lymphoblastic Leukaemia
  • Treatment of patients resistant to classical asparaginase therapy
  • Treatment of relapsing patients
  • Potential treatment of solid tumors

INVENTORS

Claudia Scotti, Maristella Maggi

 

KEYWORDS

Lymphoblastic Leukaemia relapse, L-Asparaginase mutant, Long-term storage stability, Improved thermal parameters, Outstanding proteases resistance

PRIORITY NUMBERS

PCT/EP2016/076994, US 2019/0270978

APPLICANT

Università di Pavia (100%)

Electrospun nanofibers and membrane

ABSTRACT

The society aging and the related chronic pathologies will become predominant in the next future, increasing the healthcare costs. Chronic wounds are often related to chronic diseases (as diabetes and cancer). Moreover surgeries, frequent in elderly population, and burns are often lesions difficult to heal. The platform proposed and patented develops nanofibrous scaffolds entirely based on polysaccharides as skin substitutes to achieve wound healing.

DESCRIPTION

The developed scaffolds are based on glycosaminoglycan (chondroitin sulfate or hyaluronic acid) associated to chitosan, pullulan in presence of citric acid and electrospun starting from an aqueous/acetic polymeric solution. The nanofibrous membranes are crosslinked by sterilized heating. The scaffolds have mechanical properties suitable for in vivo application. Moreover the scaffolds allow to support in vitro fibroblasts and endothelial cells adhesion and proliferation and demonstrated to enhance skin healing in an in vivo burn model (rats). The scaffolds can be easily loaded with antimicrobial agents (as silver) or chemotherapeutic agents (as norfloxacin). Moreover the systems can be reinforced with inorganic particles. The manufacture is based on electrospinning using a simple, one-step and solvent free process to obtain ultrafine and long fibers as a non-woven structure. Scale up activity and identification of critical quality attribute are on going.

ADVANTAGES

  • Employment of non-immunogenic materials
  • Solvent free preparation
  • Ease of sterilization
  • Storage at room temperature in dry state
  • Ease of scaling up

APPLICATIONS

  • Chronic non healing wounds (diabetic foot, venous leg ulcers, bed sores)
  • Burns
  • Surgical lesions
  • Infected wounds (if loaded with antimicrobial agents)

INVENTORS

Giuseppina Sandri, Maria Cristina Bonferoni, Silvia Rossi, Carla Caramella, Franca Ferrari

KEYWORDS

Chronic wounds, Implantable medical device, Glycosaminoglycans, Chitosan, Electrospinning

PRIORITY NUMBERS

PCT/IT2017/000160

APPLICANT

Università di Pavia (100%)

ARDIS SRL

PRESENTATION

ARDIS srl is a drug discovery and development company focused on the creation of antibody-based drugs for the targetedtreatment of specific cancers.

PRODUCTS AND SERVICES

Biomolecule interaction analysis service using Biacore T200, an automated system that uses the physical principle of SPR (Surface Plasmon Resonance) to analyze real-time interactions between various types of biomolecules (proteins, nucleic acids, carbohydrates, peptides, low molecular weight molecules, Viruses, bacteria, and cells) without these being labeled.

It includes:

  • Set-up (immobilization and pH-scouting) of the appropriate chip;
  • Complete analysis of the interaction;
  • Consultation or data analysis.

TEAM

Luisa Iamele, Hugo de Jonge, Claudia Scotti

CONTACTS

Claudia Scotti

Phone Number: +39 0382 986335

E-mail: info@ardis-srl.com

Website: https://sites.google.com/a/ardis-srl.com/ardis-homepage/website-builder

Subscribe to our newsletter

Subscribe to our newsletter to stay up to date with news, events and communications.